Science & STEM

Chirality Quiz: Practice chiral centers, R/S, and stereochemistry

Moderate2-5mins

This chirality quiz helps you spot chiral centers, assign R/S configurations, and tell enantiomers from diastereomers. Work through short, exam-style questions with hints and instant feedback to build speed and confidence. For 3D context, try molecular shapes practice, then broaden your review with an organic chemistry quiz.

Paper art illustration of molecular models chiral centers stereoisomers enantiomers on teal background
25Questions
InstantResults
FreeAlways
DetailedExplanations
Take the Quiz
1What does it mean for a molecule to be chiral?
2Which of these molecules possesses a chiral center?
3Enantiomers are best described as:
4Which of the following statements about meso compounds is true?
5What is a racemic mixture?
6According to Cahn[@U2013]Ingold[@U2013]Prelog rules, which substituent has the highest priority among the following?
7How many stereoisomers are possible for 2,3-dibromobutane?
8A Fischer projection is interchangeable by rotation of the molecule in the plane by:
9Which pair of stereoisomers are diastereomers?
10Which property can be used to differentiate enantiomers?
11Which of the following molecules exhibits axial chirality?
12Which of the following compounds is chiral despite lacking a stereogenic carbon atom?
13What term describes stereoisomers that arise due to restricted rotation around a bond?
14Which reagent is commonly used to resolve racemic acids by forming diastereomeric salts?
15According to the Cahn[@U2013]Ingold[@U2013]Prelog rules, which substituent has higher priority, a vinyl group ([@U2013]CH=CH2) or an ethyl group ([@U2013]CH2[@U2013]CH3)?
Learning Goals

Study Outcomes

  1. Identify Chiral Centers -

    Analyze molecular structures to locate chiral centers, reinforcing your chiral center practice and stereochemistry practice skills.

  2. Distinguish Chiral vs Achiral Molecules -

    Compare structural features to determine chirality, improving your chiral vs achiral practice and understanding of molecular symmetry.

  3. Draw Enantiomers -

    Construct accurate mirror-image representations of chiral compounds to master drawing enantiomers and solve chirality practice problems.

  4. Analyze Stereochemistry Relationships -

    Evaluate pairs of stereoisomers to classify them as enantiomers or diastereomers, leveraging stereochemistry practice problems.

  5. Apply R/S Nomenclature -

    Assign R/S configurations to stereocenters systematically, applying stereochemistry practice principles to naming chiral molecules.

  6. Evaluate Your Progress -

    Interpret instant quiz feedback to assess your strengths and target areas for improvement in chirality practice problems.

Study Guide

Cheat Sheet

  1. Identifying Chiral Centers -

    Mastering chirality practice problems starts by spotting sp³ carbons with four unique substituents, following the "all-different rule." Using Cahn - Ingold - Prelog (CIP) priorities from sources like the ACS and IUPAC helps confirm each chiral center reliably.

  2. Assigning R/S Configurations -

    Apply the CIP priority rules, orienting the lowest priority group away, then trace a path from highest to lowest (1→2→3) to determine R (clockwise) or S (counterclockwise). A handy mnemonic is "Right hand rules to the Right," reinforcing R configuration when the path curves clockwise.

  3. Distinguishing Enantiomers vs. Diastereomers -

    In chiral vs achiral practice, enantiomers are non-superimposable mirror images with opposite configurations at every chiral center, while diastereomers differ at one or more but not all centers. For instance, 2,3-butanediol has meso (achiral) and enantiomeric pairs, illustrating stereochemistry practice concepts.

  4. Understanding Racemic Mixtures and Optical Activity -

    In stereochemistry practice problems, a 1:1 mixture of enantiomers (racemate) shows no net optical rotation, while pure enantiomers rotate plane-polarized light in equal and opposite directions. Remember: "Racemic is Rotationally Neutral" to recall its zero net effect (per classical optics references).

  5. Utilizing Fischer Projections -

    Practice chiral center practice by converting wedge - dash formulas into Fischer projections, keeping horizontal substituents toward you and vertical ones away. Use the mnemonic "Horizontal Hands Hold," ensuring correct representation in stereochemistry practice.

AI-DraftedHuman-Reviewed
Reviewed by
Michael HodgeEdTech Product Lead & Assessment Design SpecialistQuiz Maker
Updated Feb 23, 2026