Science & STEM

Pedigree analysis quiz: Interpret inheritance patterns

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This quiz helps you read pedigree charts and identify autosomal, X-linked, dominant, and recessive traits. Work through clear family trees with instant feedback to build speed and accuracy for class or exams. For more practice, try punnett square practice, a genotype vs phenotype quiz, or a dominant or recessive quiz.

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1In a standard pedigree chart, which shape represents a male individual?
2What does a filled (shaded) symbol indicate in a pedigree chart?
3In a pedigree chart, a horizontal line connecting a male and a female symbol represents what?
4In a pedigree, a vertical line descending from a couple to a symbol below indicates what?
5What does a double line between two individuals in a pedigree chart usually represent?
6If a trait appears in every generation of a pedigree, which mode of inheritance is most likely?
7When a trait skips generations and appears among siblings, which inheritance pattern does this suggest?
8In X-linked recessive inheritance, which gender is more frequently affected?
9Which parent transmits mitochondrial DNA to offspring?
10Which statement best describes Y-linked inheritance?
11In a pedigree chart, what does an open (unshaded) symbol signify?
12In pedigree analysis, how is the proband (index case) indicated?
13What is the probability that two unrelated carriers of an autosomal recessive allele will have an affected child?
14In an X-linked dominant disorder, what is the expected pattern when an affected father mates with an unaffected mother?
15Which observation in a pedigree strongly suggests autosomal recessive inheritance?
16Which pedigree pattern indicates an X-linked recessive disorder?
17A carrier mother of an X-linked recessive disorder and an unaffected father have a son. What is the probability the son is affected?
18What is the probability that a child of a carrier mother and unaffected father is a carrier daughter for an X-linked recessive trait?
19Consanguinity in a pedigree increases the risk of which type of inheritance?
20If the proband's genotype is aa for an autosomal recessive trait, what is the probability that an unaffected sibling is a carrier?
21Which feature in a pedigree is most indicative of mitochondrial inheritance?
22Why are there no male 'carriers' in X-linked dominant inheritance?
23Which observation suggests genomic imprinting?
24What term describes when individuals carry a disease-causing genotype but do not exhibit the phenotype?
25Which term describes varying severity of phenotype among individuals with the same genotype?
26Which genetic phenomenon is characterized by earlier onset or increased severity in successive generations?
27A cross between two heterozygotes for a recessive lethal allele often yields which phenotypic ratio among surviving offspring?
28What does allelic heterogeneity refer to?
29What is locus heterogeneity?
30What term describes the survival advantage of heterozygous genotype in certain populations?
31What is the coefficient of inbreeding (F) for children of first cousins?
32Which term describes variable phenotype due to differing mutant mitochondrial proportions?
33Prader-Willi syndrome is most commonly caused by which genetic event?
34Angelman syndrome typically arises from which genetic alteration?
35Which formula is used to calculate the LOD (logarithm of odds) score in linkage analysis?
36In linkage analysis, a LOD score of -2 or less indicates what?
37Which recombination fraction (?) corresponds to a genetic distance of 25 centimorgans (cM)?
38What LOD score is generally accepted as significant evidence of linkage in human genetic studies?
Learning Goals

Study Outcomes

  1. Interpret Pedigree Symbols -

    Identify and understand standard symbols and notations used in pedigree charts to map family relationships and trait occurrences.

  2. Differentiate Inheritance Modes -

    Distinguish between autosomal dominant, autosomal recessive, and X-linked inheritance patterns in various family trees.

  3. Analyze X-Linked Traits -

    Examine pedigree examples to determine how X-linked traits are transmitted through maternal and paternal lines.

  4. Predict Trait Transmission -

    Apply probability concepts to forecast the likelihood of specific genetic traits appearing in future generations.

  5. Apply Pedigree Analysis Techniques -

    Use systematic approaches to solve pedigree genetics quiz scenarios and accurately infer genotypes of family members.

  6. Evaluate Real-World Pedigrees -

    Assess sample pedigrees from real or simulated cases to reinforce your understanding of genetics inheritance quiz principles.

Study Guide

Cheat Sheet

  1. Autosomal Inheritance Patterns -

    Autosomal dominant traits appear in every generation, while autosomal recessive traits can skip generations; practice with Punnett squares (e.g., Aa × Aa yields a 1:2:1 genotypic ratio). Remember "Dominant Does Display," a quick mnemonic that dominant traits will always show if at least one allele is present. Reviewing examples like cystic fibrosis (recessive) vs. Huntington's disease (dominant) from university genetics courses helps solidify these patterns.

  2. X-Linked Traits Interpretation -

    X-linked recessive traits often affect males more severely since they have only one X chromosome (e.g., colorblindness). Use the phrase "X Marks the Spot" to recall that the defective allele is on the X chromosome - females need two copies to express, while males need only one. Checking pedigree squares (males) and circles (females) for shaded symbols will help you ace the X-linked traits quiz section.

  3. Pedigree Symbols & Conventions -

    Standard symbols include squares for males, circles for females, shaded shapes for affected individuals, and arrows indicating the proband; knowing these conventions lets you quickly interpret any pedigree genetics quiz. Annotate each generation with Roman numerals (I, II, III) and individuals with Arabic numerals (1, 2, 3) to track inheritance clearly. Reliable guides from genetics textbooks and NIH resources reinforce these symbolic rules.

  4. Calculating Carrier Risks -

    When parents are unaffected but have an affected child, use conditional probability (e.g., a 2/3 chance a sibling is a carrier in autosomal recessive pedigrees) to predict risk. Constructing small Punnett squares and applying Bayes' theorem helps refine carrier probability estimates in complex families. Practice problems from reputable university problem sets will sharpen your pedigree analysis quiz skills.

  5. Recognizing Non-Mendelian Patterns -

    Mitochondrial inheritance passes exclusively from mother to all children, so look for maternal-line only transmission - no male-to-offspring transmission ever. Remember "Maternal Mitos Always Matter" as a mnemonic to distinguish these traits from autosomal or X-linked patterns. Reviewing case studies in genetics journals ensures you spot exceptions on your genetics inheritance quiz.

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Michael HodgeEdTech Product Lead & Assessment Design SpecialistQuiz Maker
Updated Feb 23, 2026